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Orochimaru's juinjutsu: the Cursed Seal of Heaven applied on Sasuke Uchiha.
Juinjutsu (呪印術; Literally meaning "Cursed Seal Techniques") are a type of jutsu used to bring someone under the control of the user. By applying a seal to the victim's body, the user brings the victim's abilities and actions under his/her control. With a simple secret hand seal, the user can inflict great mental and physical torment on the victim. The exact workings of juinjutsu are kept secret.